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Protein engineering and generation of new optogenetic tools (Postdoc and PhD student) in Frankfurt, Germany
The Gottschalk lab at the Buchmann Institute of Molecular Life Sciences (BMLS),
Goethe University, Frankfurt, Germany, seeks an experienced postdoctoral
researcher with a solid background in protein engineering, particularly of integral membrane proteins. The project, initially funded for 2 years from January 2013, aims to generate new light-driven actuators and inhibitors of neuronal activity for optogenetic applications, based on engineered microbial rhodopsins and other ion channels. This project is funded by the Cluster of Excellence Frankfurt, Macromolecular Complexes (www.cef-mc.de). A strong background in protein biochemistry and structural biology, as well as molecular biology is required to facilitate this “protein design” project. Furthermore, solid knowledge of neurobiology is necessary, and applicants should be enthusiastic to promote new approaches in neurobiology.
In addition, we offer a PhD student position to generate optogenetic tools by
modification and sub-cellular targeting of rhodopsins, as well as rhodopsin-based optical indicators of neuronal activity, to study nervous system function in the nematode C. elegans, particularly in the generation of behavior. Your background includes solid experience in molecular and cell biology, as well as cellular neuroscience, and you share a strong interest in how neuronal circuits generate behavior. This project is funded by the Collaborative Research Center 807 (www.sfb807.de), initially for 1 year from January 2013, and up to 4 years.
For both projects, experience in C. elegans neurobiology would be helpful, but is not essential. The group is interested in molecular and cellular neurobiology of C. elegans and has a strong background in optogenetics (e.g. Curr. Biol. (2005) 15: 2279, Nature (2007) 446: 633, Nature Methods (2008) 5: 895, Nature Methods (2011) 8: 153, Curr. Biol. (2012) 22: 743). See websites for more info:
www.biochem.uni-frankfurt.de/index.php
www.fmls-institute.de/index.php
Please send your resume, including CV, research experience, publications, and
addresses of three references, no later than December 9th, 2012, by e-mail to
Alexander Gottschalk (a.gottschalk@em.uni-frankfurt.de).
Research Group Vabulas
The Protein Aggregation Group of Dr. Martin Vabulas at the Goethe University in Franfurt am Main invites
two full-time post-doctoral researchers (E13 TV-G-U)
to join the project „Metastability of proteins during tumor metastasis“. The positions are available from March 1st, 2013 and are limited for two years with a possible extension.
The project is funded by the European Research Council (ERC) Consolidator Grant and is going to exploit biochemical and genomic approaches in murine models to address the role of the molecular chaperones in tumorigenesis.
The group is part of the Buchmann Institute for Molecular Life Sciences (www.bmls.de) and the Cluster of Excellence „Macromolecular Complexes“ (www.cef-mc.de) which strongly support interdisciplinary research and the development of cutting-edge technologies.
The project includes systematic modification of bacterial artificial chromosomes of the HSP70 superfamily members to create a pannel of metastatic cell lines with regulatable amounts of the respective chaperones. Subsequently, these cell lines will be expanded in vivo and analysed ex vivo by mass spectrometry and next-generation sequencing. The goal is to identifiy substrate-chaperone pairs which are required for tumor metastasis and which might serve as new therapeutic targets.
The applicants should be interested in biochemical and genomic analyses of animal tumor models; the respective expertise is essential for application. Training certificates considering animal experiments must be provided with other documents including three letters of recommendation.
For all questions please contact Dr. Martin Vabulas (vabulas@em.uni-frankfurt.de, Phone: 069-79842568). Please submit all your documents as one pdf-file until February 15th, 2013.
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