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Methods for Studying Macromolecular Complexes

Research Area E

During its first five years, CEF invested substantial resources into the access to new methods for the analysis of macromolecular complexes. The range of technologies now includes advanced light microscopy, electron microscopy, magnetic resonance spectroscopy, time-resolved optical and IR-spectroscopy and mass spectrometry. They encompass spatial scales from atomic to organismal, concentrations from attomolar to molar, energies from neV to MeV, and time scales from femtoseconds to seconds. During the next five years, we will focus on an integrated approach to structure and function in biology. We will analyze single molecules and will cover cellular sections, three-dimensional cultures as well as whole organisms and small tissue sections.


Strategic goals:

• Integrating methods that provide different scales in terms of energy, spatial and temporal resolution
• Fostering collaborations between physics, chemistry, mathematics, bioinformatics
and the life sciences
• Placing cells in context



Time and length scales of the spectroscopic and microscopic techniques at CEF
for investigation of structures and dynamics of macromolecular complexes