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CEF Focus Projects Programme

This programme provides seed funds for projects tackling important scientific questions that, although holding the promise of major gains, would not be financially supported by funding organizations due to the high risk of failure involved. CEF focus projects typically exploit the complementary scientific expertise of CEF. Each project is coordinated by a CEF Principal Investigator. The project teams can include scientists who are not CEF members.


CEF focus projects funded:

Ubiquitin modifications as key signaling hubs for the regulation of survival and of cell death pathways (FP2)   
Ivan Dikic, Volker Dötsch, Simone Fulda, Mike Heilemann & Ina Koch

Microbial rhodopsins as a tool to develop novel light-gated ion channels (FP4)   
Clemens Glaubitz, Alexander Gottschalk, Thomas Prisner, Josef Wachtveitl & Christian Bamann

Optochemical biology:  in-situ membrane receptor clustering by light (FP5)   
Robert Tampé, Mike Heilemann &  Ralph Wieneke

Discovery, structure and function of eukaryotic riboswitches in plants (FP10)    
Harald Schwalbe, Enrico Schleiff & Jens Wöhnert

Characterization of mechanisms controlling circular RNAs generation (FP11)   
Stefanie Dimmeler, Michaela Müller-McNicoll & Kathi Zarnack

Ubiquitin-like proteins of the human ATG8 family in spatio-temporal regulation of protein complexes (FP12)   
Christian Behrends, Masato Akutsu, Volker Dötsch & Vladimir Rogov

Electron microscopy of mitochondrial complex I (FP13)   
Werner Kühlbrandt, Volker Zickermann & Ulrich Brandt

Structural characterization of polyketide synthases (PKSs) (FP14)   
Martin Grininger, Helge Bode & Achilleas Frangakis

Heterodimeric ABC transport complexes – from conformational dynamics to mechanism (FP15)   
Robert Tampé, Gerhard Hummer, Thomas Prisner & Eric Geertsma

Membrane-on-nanopore chip detection of antibiotic excretion by three-component efflux pumps (FP16)   
Klaas Martinus Pos & Robert Tampé