December 2018. Light-controlled TAP inhibitor expands the repertoire of chemical intervention tools for the study of immunological processes

December 2018. New riboswitch aptamer with selective and isomer-specific binding to a novel photoswitchable ligand suitable for biological applications

December 2018. Structure-guided fluorescence labelling reveals a two-step binding mechanism of neomycin to its RNA aptamer

December 2018. Scientists from Johannes Gutenberg University, IMB, TU Darmstadt, LMU and Goethe University have joined forces to establish a new research hub in this biomedically highly relevant field

November 2018. Ivan Dikic, Stefanie Dimmeler, Stefan Knapp and Ernst Stelzer belong to the top 1% scientists cited

November 2018. The research training group "Complex Scenarios of Light-Control" has successfully applied for a second funding period

November 2018. Advanced spectroscopic approaches reveal unexplored nucleotide binding modes for the ABC exporter MsbA

November 2018. The Society for Neuroscience recognizes Erin Schuman for her outstanding achievements in neuroscience and for promoting the professional advancement of women

November 2018. Food sensation modulates locomotion by dopamine and neuropeptide signaling in a distributed neuronal network

October 2018. The biochemist Robert Tampé will receive € 1.5 million for a Koselleck project with the German Research Foundation starting in 2019

October 2018. Topological inversion of rhodopsins yields new variants with unique properties

October 2018. High-throughput strategy to simultaneously target multiple endogenous proteins in living cells with nanometer resolution

October 2018. The Max Planck Institute of Biophysics has announced that Ivan Dikic has been appointed a Fellow of the Max Planck Society for a 5-year-term. This includes supervision of a small working group at the Frankfurt-based...

September 2018. Joint project between Justus-Liebig-University, Goethe University and Max-Planck-Institute clears the last hurdle

September 2018. Minister stellt das Frankfurt Cancer Institute vor, das am Campus Niederrad entstehen wird

September 2018. Functionally asymmetric motor neurons contribute to the coordination of C. elegans movement

September 2018. TrisNTA fluorophores allow specific labeling and increased photostability

September 2018. High-throughput mutagenesis approach decodes a cancer-relevant splicing decision in the RON proto-oncogene

September 2018. Understanding the intricate coupling of protein and RNA folding dynamics that enable translation initiation of structured mRNAs

August 2018. Neurovascular communication in the brain

July 2018. Method enables incorporation of a wide range of modifications at any desired position in RNAs of any lengths

July 2018. Correlative single-molecule FRET and DNA-PAINT imaging opens the door for accurate distance readout in the 1–10 nm range

July 2018. Hartmut Michel’s presentation to an international audience of young scientists is available online

July 2018. With the complexities of organelle communication and their dynamics under intense investigation, what are the new principles that are emerging, and where is the field headed?

June 2018. New method to study dynamics of biomolecules with atomistic resolution at physiological temperature

June 2018. Scaffold design of trivalent chelator heads dictates high-affinity and stable His-tagged protein labeling in vitro and in cellulo

May 2018. Frankfurt scientists reveal atomic details for one of Legionella’s enzymatic weapons and develop first inhibitor

May 2018. Transparent chip design provides parallel and independent fluorescent readout of both cavities and buffer reservoir for unbiased single-transporter recordings

May 2018. High-resolution cryo-EM structure of an intact chloroplast ATP synthase provides new insights into an ancient biological process

May 2018. Bridge between epigenetics and cancer treatment

May 2018. Optical cochlear implants restore auditory nerve activity in deaf mice

April 2018. Innovative selective small molecule modulators of protein function now available as new tools for the scientific community

April 2018. Alternative 3′ UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments

April 2018. Full scholarships available for excellent applicants from all over the world with a first degree from a non-German university

April 2018. EU supports research in Frankfurt on the immune response in cells with 2.5 million Euro

April 2018. Strategy to prolong inhibitor residence times to increase efficacy of medical drugs

March 2018. Early functional dynamics of channelrhodopsin-2 explored through molecular simulations

March 2018. Science correspondent interviews Erin Schuman and other MPI directors

March 2018. New universal vector concept for direct genotyping of transgenic organisms and systematic creation of homozygous lines

March 2018. Mutual arrangement of the two largest components of the respiratory chain is essentially the same in mammals, plants and yeast, indicating that this arrangement is important for electron transfer

March 2018. Kinetic and simulation framework contributes to understanding of transcriptional riboswitches

February 2018. New chelators permit kinetic profiling, multiplexed labeling of His6 and His12-tagged proteins as well as single-molecule based super-resolution imaging

February 2018. Activation of p63 in oocytes requires consecutive interplay of CHK2 and CK1 kinases

February 2018. Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses

February 2018. Childhood cancer expert Simone Fulda elected by the senate of Goethe University as vice-president for research and academic infrastructure.

January 2018. Mature endothelial cells have the capacity to clonally expand and contribute to ischemia-induced newly formed vessels

January 2018. Protein aggregation of the p63 transcription factor cause the severe skin fragility in AEC syndrome

January 2018. The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

January 2018. Lab Times ranking lists Stefan Knapp as the 10th most cited European protein scientist

January 2018. Study solves puzzle how closely related receptors with high sequence similarity differentiate between very similar peptides