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News Archive

Correlative single-molecule FRET and DNA-PAINT imaging

July 2018. Correlative single-molecule FRET and DNA-PAINT imaging opens the door for accurate distance readout in the 1–10 nm range

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68th Lindau Nobel Laureate Meeting

July 2018. Hartmut Michel’s presentation to an international audience of young scientists is available online

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Complexities of organelle biology

July 2018. With the complexities of organelle communication and their dynamics under intense investigation, what are the new principles that are emerging, and where is the field headed?

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Dynamics of nucleic acids at room temperature revealed by pulsed EPR

June 2018. New method to study dynamics of biomolecules with atomistic resolution at physiological temperature

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Optimizing nanotool structure for tracking proteins

June 2018. Scaffold design of trivalent chelator heads dictates high-affinity and stable His-tagged protein labeling in vitro and in cellulo

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Complementing conventional antibiotics

May 2018. Frankfurt scientists reveal atomic details for one of Legionella’s enzymatic weapons and develop first inhibitor

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Silicon chips with transparent microcavities for high-throughput optical studies of single membrane proteins

May 2018. Transparent chip design provides parallel and independent fluorescent readout of both cavities and buffer reservoir for unbiased single-transporter recordings

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Structure, mechanism, and regulation of the chloroplast ATP synthase

May 2018. High-resolution cryo-EM structure of an intact chloroplast ATP synthase provides new insights into an ancient biological process

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Stefan Knapp elected EMBO member

May 2018. Bridge between epigenetics and cancer treatment

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High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics

May 2018. Optical cochlear implants restore auditory nerve activity in deaf mice

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Donated chemical probes for open science

April 2018. Innovative selective small molecule modulators of protein function now available as new tools for the scientific community

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Dynamics of untranslated regions of neuronal mRNA molecules

April 2018. Alternative 3′ UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments

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Scholarships available for international Goethe University Master students

April 2018. Full scholarships available for excellent applicants from all over the world with a first degree from a non-German university

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Robert Tampé receives ERC Advanced Investigator Grant

April 2018. EU supports research in Frankfurt on the immune response in cells with 2.5 million Euro

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Halogen‐aromatic pi-interactions modulate inhibitor residence time

April 2018. Strategy to prolong inhibitor residence times to increase efficacy of medical drugs

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Water emerges as key player in the opening of a membrane channel important in optogenetics

March 2018. Early functional dynamics of channelrhodopsin-2 explored through molecular simulations

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Opportunities for female scientists

March 2018. Science correspondent interviews Erin Schuman and other MPI directors

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AGameOfClones for genotyping of transgenic model organisms

March 2018. New universal vector concept for direct genotyping of transgenic organisms and systematic creation of homozygous lines

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Conserved arrangement of complex I and III2 in mitochondrial respiratory chain supercomplexes

March 2018. Mutual arrangement of the two largest components of the respiratory chain is essentially the same in mammals, plants and yeast, indicating that this arrangement is important for electron transfer

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Life times of metastable states guide regulatory signaling in transcriptional riboswitches

March 2018. Kinetic and simulation framework contributes to understanding of transcriptional riboswitches

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Super-chelators for advanced protein labeling in living cells

February 2018. New chelators permit kinetic profiling, multiplexed labeling of His6 and His12-tagged proteins as well as single-molecule based super-resolution imaging

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New target for fertility protective therapy

February 2018. Activation of p63 in oocytes requires consecutive interplay of CHK2 and CK1 kinases

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New proteins for new memories

February 2018. Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses

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Simone Fulda elected vice-president of Goethe University Frankfurt

February 2018. Childhood cancer expert Simone Fulda elected by the senate of Goethe University as vice-president for research and academic infrastructure.

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Clonal expansion of endothelial cells contributes to blood vessel growth

January 2018. Mature endothelial cells have the capacity to clonally expand and contribute to ischemia-induced newly formed vessels

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Cause of severe hereditary disease revealed

January 2018. Protein aggregation of the p63 transcription factor cause the severe skin fragility in AEC syndrome

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Regulation of endothelial gene expression by a long non-coding RNA

January 2018. The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

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Stefan Knapp is among the most cited protein scientists in Europe

January 2018. Lab Times ranking lists Stefan Knapp as the 10th most cited European protein scientist

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Subtype specificity in human peptide GPCRs by DNP-enhanced solid-state NMR

January 2018. Study solves puzzle how closely related receptors with high sequence similarity differentiate between very similar peptides

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