english deutsch 

News Archive

When quality control fails

June 2015. Defects in the quality control systems of cells are often fatal. This is seen in particular in neurodegenerative diseases such as Alzheimer's or Parkinson's. As published in the online version of the journal Nature on 3 June, a research team led by Ivan Dikic discovered a new autophagy receptor which plays a central role in cellular quality control. Mutations in this receptor impair its function and cause a hereditary neuropathy named HSAN II. This milestone study not only gives insight into the pathophysiology of a disastrous disease, but also emphasizes the importance of the autophagy network for the wellbeing of cells.

Further information:

English press release

German press release

Original article

Ivan Dikic
Institute of Biochemistry II
Buchmann Institute for Molecular Life Sciences
Goethe University Frankfurt
Frankfurt (Main), Germany
Tel.: +49 (0)69 6301-5964


Full reference:
Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I (2015) Regulation of endoplasmic reticulum turnover by selective autophagy. Nature, published online 3 June 2015, doi:10.1038/nature14498