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DFG approves CRC 1361 on DNA repair and genome stability

December 2018. The genetic information in our cells is at constant risk of damage, and sophisticated DNA repair mechanisms have evolved to maintain genome stability. Whilst many of the mechanisms have been studied in molecular detail, their regulation and concerted action is still unclear. A new collaborative research center (CRC 1361) on this topic has now received funding from the German Research Foundation (DFG). Under the leadership of Helle Ulrich of Johannes Gutenberg University Mainz (JGU), scientists from Institute of Molecular Biology gGmbH (IMB) in Mainz, Technische Universität Darmstadt, Ludwig-Maximilians-Universität München and Goethe University Frankfurt have joined forces to establish a new research hub in this biomedically highly relevant field. The CRC will receive initially about 10 Mio Euro for four years. CEF member Ivan Dikic will participate with a project focusing on the replication stress response. The team will analyze mechanisms removing damage like DNA-protein crosslinks which would otherwise result in stalling of replication forks, and will look into cellular strategies of telomere replication.

Link to English press release by JGU Mainz

Link to German press release by JGU Mainz

Link to Press Release by Goethe University

Link to DFG press release



Helle Ulrich, Johannes Gutenberg University & Institute of Molecular Biology, Mainz, Germany, h.ulrich@imb.de

Ivan Dikic, Institute of Biochemistry 2 & Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt/Main, Germany, dikic@biochem2.uni-frankfurt.de