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In situ assembly of macromolecular complexes triggered by light

In the journal Proceedings of the National Academy of Sciences Frankfurt scientists report how "light switches" can be used to control biomolecular interactions. The concept opens up new applications in the production of novel biochips as well as in research and regulation of cellular processes - with very high temporal and spatial resolution. These new insights allow for example the capture and detection of rhinoviruses - one of the most common causes for colds - by light-triggered receptors.

Grunwald C, Schulze K, Reichel A, Weiss VU, Blaas D, Piehler J, Wiesmüller KH, Tampé R (2010) In situ assembly of macromolecular complexes triggered by light. P Natl Acad Sci USA 107:6146-6151

 

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Contact:
Prof. Dr. Robert Tampé
Institute of Biochemistry, Biocenter
Goethe University Frankfurt
Max-von-Laue-Straße 9, D-60438 Frankfurt/Germany
Phone: +49-(0)69-798 29475/76
Fax: +49-(0)69-798 29495
Email: tampe@em.uni-frankfurt.de
Homepage: http://www.biochem.uni-frankfurt.de/index.php?id=10