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Caged glutathione: Triggering protein interaction by light

9 March 2012. Caged glutathione is a new way to trigger protein interaction by light. Glutathione (GSH) fulfills a universal role as redox factor, scavenger of reactive oxygen species, and as an essential substrate in the conjugation, detoxification, and reduction reactions catalyzed by glutathione S-transferase (GST). In their Communication in the Journal Angewandte Chemie International Edition, Alexander Heckel, Robert Tampé and co-workers describe how GST fusion proteins could be assembled in situ at variable density by laser-scanning activation. More ...

 

Cover image in Angewandte Chemie

Contacts:
Robert Tampé
Institut für Biochemie
Goethe-Universität Frankfurt
Max-von-Laue-Straße 9
60438 Frankfurt am Main
Tel: +49-(0)69-798 29475/76
tampe@em.uni-frankfurt.de

Alexander Heckel
Prof. Dr. Alexander Heckel
Institut für Organische Chemie
Buchmann Institute for Molecular Life Sciences Goethe Universität Frankfurt Max-von-Laue-Str. 7
60438  Frankfurt am Main
+49 (69) 798 - 42505
heckel@em.uni-frankfurt.de

Full reference:  Volker Gatterdam, Tatjana Stoess, Clara Menge, Alexander Heckel and  Robert Tampé (2012). Caged Glutathione: Triggering Protein Interaction by Light. Angewandte Chemie International Edition  Vol. 51, Issue 11, first published online: 8 MAR 2012 (DOI: 10.1002/anie.201201327) More ....